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"Silverstein, Alvin"
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Handy health guide to burns and blisters
\"Have you ever touched a hot pan by accident? You may have even gotten slightly burned when you did. Authors Alvin and Viriginia Silverstien and Laura Silverstein Nunn explore the different types of burns you can get, and how to best prevent burns, blisters, and sunburns.\"-- Provided by publisher.
Book
Handy health guide to diabetes
\"Find out what diabetes is, the different kinds of diabetes, diabetes testing, and how to treat it\"-- Provided by publisher.
Book
Handy health guide to asthma
\"An overview of asthma for children in grades 5 and up. Find out what asthma is, what causes it, how it is diagnosed, and some treatment options\"-- Provided by publisher.
Book
Handy health guide to colds and flu
\"An overview about colds and the flu--how germs are spread, how to treat these diseases, and how to avoid becoming sick\"-- Provided by publisher.
Book
Our Children Will Live Forever
We live each day as though we were immortal. The thought that death may claim us seems to have no immediacy. It is always the other guy\" who will be killed on the highway or be struck down by a heart attack or waste away with an incurable cancer.
Newspaper Article
Handy health guide to your eyes
\"Find out about the parts of the human eye and how we see, why things are blurry, if you need glasses or contacts, and how to take care of your eyes\"-- Provided by publisher.
Book
Platelet-derived S100 family member myeloid-related protein-14 regulates thrombosis
Expression of the gene encoding the S100 calcium-modulated protein family member MRP-14 (also known as S100A9) is elevated in platelets from patients presenting with acute myocardial infarction (MI) compared with those from patients with stable coronary artery disease; however, a causal role for MRP-14 in acute coronary syndromes has not been established. Here, using multiple models of vascular injury, we found that time to arterial thrombotic occlusion was markedly prolonged in Mrp14⁻/⁻ mice. We observed that MRP-14 and MRP-8/MRP-14 heterodimers (S100A8/A9) are expressed in and secreted by platelets from WT mice and that thrombus formation was reduced in whole blood from Mrp14⁻/⁻ mice. Infusion of WT platelets, purified MRP-14, or purified MRP-8/MRP-14 heterodimers into Mrp14⁻/⁻ mice decreased the time to carotid artery occlusion after injury, indicating that platelet-derived MRP-14 directly regulates thrombosis. In contrast, infusion of purified MRP-14 into mice deficient for both MRP-14 and CD36 failed to reduce carotid occlusion times, indicating that CD36 is required for MRP-14-dependent thrombosis. Our data identify a molecular pathway of thrombosis that involves platelet MRP-14 and CD36 and suggest that targeting MRP-14 has potential for treating atherothrombotic disorders, including MI and stroke.
Journal Article